CAT 2025 Question Paper | VARC Slot 3

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Question 13 : The given sentence is missing in the paragraph below. Decide where it best fits among the options 1, 2, 3, or 4 indicated in the paragraph.

Sentence: In each of the affected males, the genetic defect was located to the X chromosome in the region of p11-12.

Paragraph: The first suggested evidence of a human genetic mutation associated with aggressive behaviour came from a study in 1993. _____(1)____. Genetic and metabolic studies were conducted on a large Dutch family in which several of the males has a syndrome of borderline mental retardation and abnormal behaviour. _____(2)____. The undesirable behaviour included impulsive aggression, arson and exhibitionism. _____(3)____. A point mutation was identified in the eighth exon of the monoamine oxidase A (MAOA) structural gene which changes glutamine to a termination codon. _____(4)____.

Explanatory Answer

The missing sentence is about the location of a genetic defect in affected males. Blank 1 is easily ruled out as the context is not right to introduce the missing sentence here. The sentence before blank 2 talks of 'abnormal behaviour' and the one that follows it explains what the undesirable behaviour included. Placing the missing sentence in blank 2 will break this logical flow of ideas. So, blank 2 is also ruled out. The sentence that follows blank 3 seems to be very specific in terms of the mutation it describes. The missing sentence is more general and relates to the 'affected males' from the study. So, the missing sentence fits in blank 3, not 4.

The answer is 'Option 3'

Choice 3 is the correct answer.

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